HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 708400Generated: October 30, 2026
Methylhydrazine → (S)-tert-butyl 2-(aminooxy)propanoate
https://huagongshe.com/reaction/708400
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | Propanoic acid,2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-,1,1-dimethylethyl ester,(2S)- | HCID 57751243 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-tert-butyl 2-(aminooxy)propanoate | HCID 118379554 | — |
Reaction Steps
To a solution of (S)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)oxy)propanoate (73.3 mg, 0.252 mmol) in DCM (Volume: 500 μL) at 0° C. was added methyl hydrazine (13.5 μL, 0.252 mmol). After stirring for 3 h at 0° C., the solids were filtered off and the filtrate was concentrated in vacuo, affording the title compound (assumed quantitative) as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09174978B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-8c5f0762f0e644829567bad5d32795ad |
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| Source note | uspto-grants-2015_11 |
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