Dichloromethane → HCID 178454250, compound

Participants

Reaction Steps

To a solution of 2-(((Z)-(2-(((2R,3S)-2-((4-(ammoniomethyl)-1H-1,2,3-triazol-1-yl)methyl)-4-oxo-1-sulfoazetidin-3-yl)amino)-1-(2-aminothiazol-4-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate (150 mg, 0.122 mmol) In DCM (10 mL) was added DIPEA (100 μL, 0.610 mmol) followed N,N-di-Boc-1H-pyrazole-1-carboxamidine (42 mg, 0.134 mmol). The solution was stirred at RT overnight whereupon it was concentrated in vacuo, water was added and it was lyophilized for 72 h to afford crude title compound (210 mg, assumed quantitative conversion). LCMS: m/z=772.1 (M−1).

Provenance & Evidence