HCID 131733770, compound → HCID 118379509, compound

HRID 708432Notes

Reaction equation

HRID 708432 reaction equation
[CH3:1][C:2]1[N:6]([CH2:7][C@@H:8]2[C@H:11]([NH:12]C(=O)OCC3C=CC=CC=3)[C:10](=[O:23])[NH:9]2)[N:5]=[CH:4][N:3]=1>CO.[Pd]>[NH2:12][C@H:11]1[C@@H:8]([CH2:7][N:6]2[C:2]([CH3:1])=[N:3][CH:4]=[N:5]2)[NH:9][C:10]1=[O:23]

Participants

4

Reactant 1

HCID 131733770HCID 131733770, compound

Product 1

HCID 118379509HCID 118379509, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A slurry of benzyl ((2R,3S)-2-((5-methyl-1H-1,2,4-triazol-1-yl)methyl)-4-oxoazetidin-3-yl)carbamate (240 mg, 0.76 mmol) and Pd on C (10%, 100 mg) in MeOH (20 mL) was evacuated and backfilled with H2 (3×), bringing the final pressure to 35 psi. After 2 h of stirring the mixture was filtered over celite, washing with MeOH and the filtrate was concentrated in vacuo. The crude residue was used as such in the following step.

Workup

  1. filtrationwas filtered over celite
  2. washwashing with MeOH
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-64191c7e480646f99a60da1e0e8acb21
Source dataset
uspto-grants-2015_11
Patent number
US09174978B2

Reaction notes

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