Sodium borohydride → HCID 118379551, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-(((2R,3S)-3-(((benzyloxy)carbonyl)amino)-4-oxoazetidin-2-yl)methyl)-2,4-dioxoimidazolidine-1-carboxylate (170 mg, 0.390 mmol) in EtOH (10 mL) at 0° C. was added sodium borohydride (30 mg, 0.78 mmol). After 3 h at 0° C., the mixture was quenched with saturated NH4Cl (aq) and partially concentrated in vacuo. The bilayer was extracted with DCM and the organic layer was dried over Na2SO4 and concentrated in vacuo. The resulting residue was used as such in step 5. LCMS: m/z=457.1 (M+Na).

Provenance & Evidence