Acetonitrile → Benzyl ((2R,3S)-2-((1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-4-oxoazetidin-3-yl)(4-methoxybenzyl)carbamate

Participants

Role	Name	HCID	Charge
Reactant	Acetonitrile	HCID 6342	—
Reactant	Potassium Persulfate	HCID 24412	—
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	Benzyl ((2R,3S)-2-((1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)(4-methoxybenzyl)carbamate	HCID 118379592	—
Solvent	Water	HCID 962	—
Product	Benzyl ((2R,3S)-2-((1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-4-oxoazetidin-3-yl)(4-methoxybenzyl)carbamate	HCID 118379866	—

Reaction Steps

Prepared in analogous manner to example 82 step 5, using benzyl ((2R,3S)-2-((1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)(4-methoxybenzyl)carbamate (57.2 mg, 0.080 mmol), CH3CN (762 μl), water (381 μl), potassium peroxydisulfate (31 mg, 0.12 mmol), and potassium phosphate, dibasic (19 mg, 0.109 mmol). 20.2 mg. LCMS: Rt=0.89 min, m/z=565.3 (M+1). Method 2m_acidic.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09174978B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-03c1bf20c4d2468b8ec4d6e8dec52f68
Source note	uspto-grants-2015_11