Acetone → HCID 131733809, compound

Participants

Reaction Conditions

Reaction Steps

Prepared according to the procedure described by Jubian at al. Angew. Chem, 1995, 107, 1343 and Rasmussen et al. Synthesis, 1988, 456. To a solution of benzoyl isothiocyanate (0.93 g, 5.70 mmol) in acetone (10 mL) was added tert-butyl(3-aminopropyl)carbamate (0.95 g, 5.45 mmol). After heating at 60° C. for 2.5 h, the reaction mixture was concentrated in vacuo. The crude residue was purified via silica gel chromatography (EtOAc-heptane, 0-40%), affording the title compound (0.83 g, 43%). LCMS: Rt=0.93 min, m/z=338.0 (M+1) Method 2m_acidic.

Provenance & Evidence