Potassium Phosphate, Dibasic → HCID 118379379, compound

Participants

Reaction Conditions

Reaction Steps

Prepared in an anologous manner as example 4, step 2 using (2-(((2R,3S)-3-(((benzyloxy)carbonyl)amino)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-2-yl)methyl)-2H-1,2,3-triazol-4-yl)methyl 3-(((tert-butoxycarbonyl)amino)methyl)azetidine-1-carboxylate (410 mg, 0.591 mmol), K2S2O8 (272 mg, 1.01 mmol) and K2HPO4 (165 mg, 0.946 mmol) in ACN:water (2:1, 7.2 mL) while heating for 5 h at 90° C. The crude residue was purified via silica gel chromatography (EtOAc-Heptane, 30-90%), affording the title compound (80 mg, 25%) as a solid. LCMS: Rt=0.78 min, m/z=544.2 (M+1) Method 2m_acidic.

Provenance & Evidence