HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 708622Generated: October 25, 2026
Hydrochloric Acid → (S)-2-Amino-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester dihydrochloride
https://huagongshe.com/reaction/708622
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-2-tert-Butoxycarbonylamino-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester | HCID 58327260 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-2-Amino-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester dihydrochloride | HCID 66719184 | — |
Reaction Steps
(S)-2-tert-Butoxycarbonylamino-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester (0.2 g) was taken in 4 mL of DCM and cooled to 0° C. and HCl (1 mL, 4N in dioxane) was added and reaction was stirred at room temperature for 2 hours. All volatiles were evaporated and residue was triturated with DCM/hexanes (0.17 g). LCMS (m/z): 302.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09175003B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-592177a5e13240a2aa1b24bce2ec4d77 |
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| Source note | uspto-grants-2015_11 |
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