Hydrochloric Acid → HCID 117739242, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Intermediate 3D (8.1 g, 33.7 mmol) in acetonitrile (100 mL) was added 4.0N HCl in dioxane (25.3 mL, 101 mmol). The mixture was stirred at 65° C. for 1.5 h. HPLC and LCMS indicated complete conversion of starting material. Solvent was removed to give Intermediate 3E (8.1 g, 33.1 mmol, 98% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.38-8.46 (m, 2H) 8.31 (dd, J=8.79, 2.20 Hz, 1H) 7.61 (d, 1H); 19F NMR (376 MHz, DMSO-d6) δ ppm −160.17 (s., 1F); MS (ESI) m/z: 209.2 (M+H)+.

Provenance & Evidence