Hydrochloric Acid → HCID 118093131, compound

Participants

Reaction Steps

To a solution of 3B (2 g, 6.09 mmol) in EtOAc (30 mL) was added 4.0 N HCl in dioxane (30.4 mL, 122 mmol) and the mixture was stirred at r.t. for 2 h. Solvent was removed under reduced pressure to give 3C (1.8 g, 6.27 mmol, 99% yield) as a off white solid. 1H NMR (400 MHz, CD3OD) δ ppm 7.79 (d, J=8.79 Hz, 1H) 7.03 (d, J=2.20 Hz, 1H) 6.96-7.02 (m, 1H) 4.33 (s, 2H) 3.24 (q, J=7.47 Hz, 2H) 2.75 (s, 3H) 1.24 (t, J=7.47 Hz, 3H).

Provenance & Evidence