HCID 118098697, compound → HCID 118092693, compound

Participants

Reaction Steps

To a suspension of 6D (327 mg, 0.749 mmol) in MeOH (10 mL), was added 10% Pd—C (40 mg, 0.038 mmol). The mixture was evacuated and flushed with H2 (3×), then was stirred under an atmosphere of H2 for 7.5 h. The reaction mixture was filtered and concentrated to give 6E (203 mg, 99% yield) as a colorless semisolid. MS (ESI) m/z: 273.2 [M+1]+. 1H NMR (400 MHz, methanol-d4) δ ppm 7.58 (d, J=8.78 Hz, 1H) 6.69 (d, J=2.51 Hz, 1H) 6.64 (dd, J=8.66, 2.38 Hz, 1H) 3.78-3.89 (m, 2H) 3.59-3.67 (m, 1H) 3.44-3.55 (m, 2H) 3.21 (s, 3H) 2.37 (s, 3H) 1.28 (d, J=6.78 Hz, 3H).

Provenance & Evidence