Water → HCID 118098706, compound

Participants

Reaction Conditions

Reaction Steps

10A (3.22 g, 7.02 mmol) was dissolved in DMSO (25 mL), lithium chloride (0.596 g, 14.05 mmol) and water (0.152 mL, 8.43 mmol) were added. The reaction mixture was stirred at 130° C. for 3 h, then was cooled to rt, diluted with EtOAc (250 mL), washed with water (2×100 mL), brine (1×100 mL) and dried (Na2SO4). EtOAc was removed under reduced pressure and the crude product was purified by flash chromatography to give 10B (850 mg, 31.3% yield); MS (ESI) m/z: 386.9 (M+H)+.

Provenance & Evidence