HCID 118098723, compound → HCID 118098724, compound

HRID 708846Notes

Reaction equation

HRID 708846 reaction equation
C(O[C:9]([N:11]([CH2:13][C:14]1[CH:19]=[C:18]([N+:20]([O-])=O)[CH:17]=[CH:16][C:15]=1[C@@H:23]([CH2:28][CH3:29])[C:24]([O:26][CH3:27])=[O:25])C)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:20][C:18]1[CH:17]=[CH:16][C:15]([C@@H:23]([CH2:28][CH3:29])[C:24]([O:26][CH3:27])=[O:25])=[C:14]([CH2:13][NH:11][CH3:9])[CH:19]=1

Participants

4

Reactant 1

HCID 118098723HCID 118098723, compound

Product 1

HCID 118098724HCID 118098724, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

13D (103 mg, 2.81 mmol) was dissolved in MeOH (5 mL). 10% Pd/C was added. The reaction mixture was stirred under a hydrogen balloon for 3 h. Pd/C was removed by filtration and the filtrate was concentrated under reduced pressure to give 13E (169 mg, 0.547 mmol, 97% yield). MS (ESI) m/z: 237.0 (M+H)+.

Workup

  1. customPd/C was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a9f812706d2f42889be1b99cde27b01a
Source dataset
uspto-grants-2015_11
Patent number
US09174974B2

Reaction notes

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