Acetic Acid → 3-Fluoro-2-hydroxy-5-nitrobenzaldehyde

Participants

Reaction Conditions

Reaction Steps

To a flask with 3-fluoro-2-hydroxybenzaldehyde (5.00 g, 35.7 mmol) in acetic acid (10 mL, 175 mmol), was added nitric acid (conc., 10 mL, 244 mmol) at 0° C. The mixture was stirred 0° C. for 30 min, quenched with ice, extracted with EtOAc (3×30 mL). The combined organic layer was washed with brine, dried (Na2SO4) and concentrated to give 17C (5.457 g, 29.5 mmol, 83% yield) as a yellow solid.

Provenance & Evidence