HCID 118098752, compound → HCID 118098753, compound

Participants

Reaction Steps

A mixture of 22A (2.5 g, 6.47 mmol) and Pd/C (0.25 g, 0.235 mmol) in MeOH (30 mL) were stirred under H2 (50 psi) overnight. The reaction was filtered and concentrated. The crude product was purified by flash chromatography (0% to 100% ethyl acetate in hexane) to yield 22B (1.6 g, 4.49 mmol, 69.4% yield) as a white solid. MS (ESI) m/z: 357.5 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.41 (1H, d, J=8.79 Hz), 6.53 (1H, d, J=8.79 Hz), 6.38 (1H, br. s.), 6.26 (2H, d, J=12.74 Hz), 4.66 (2H, s), 2.80 (3H, s), 1.29-1.56 (9H, m), 1.21 (9H, s).

Provenance & Evidence