Hydrochloric Acid → HCID 131733872, compound

Participants

Reaction Steps

HCl (4 M in dioxane, 5 mL) was added to 22B (500 mg, 1.403 mmol) and stirred at rt for 1 h. The reaction was concentrated to yield 22C (460 mg, 1.397 mmol, 100% yield) as a white solid. MS (ESI) m/z: 257.3 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.93 (2H, br. s.), 7.51 (1H, d, J=8.79 Hz), 6.76 (1H, d, J=2.20 Hz), 6.72 (1H, dd, J=8.79, 2.20 Hz), 4.17 (2H, t, J=5.71 Hz), 2.53 (3H, t, J=5.27 Hz), 1.21 (9H, s).

Provenance & Evidence