Diisopropylethylamine → HCID 117739360, compound

Participants

Reaction Steps

To a flask containing 27A (1.6 g, 7.99 mmol), DIEA (2.088 ml, 11.99 mmol) in DMF (10 ml), was added N-(benzyloxycarbonyloxy) succinimide (2.19 g, 8.79 mmol). The mixture was stirred at rt for 1 h. The reaction was quenched with H2O and then extracted with EtOAc (3×). The organic layer was washed with brine, dried over Na2SO4 and concentrated. The crude was purified by flash column chromatography (0-60% EtOAc/hexanes) to give 27B (1.8 g, 5.38 mmol, 67.4% yield). MS (ESI) m/z: 335.2 (M+H)+.

Provenance & Evidence