Imidazole → HCID 131733874, compound

Participants

Reaction Steps

To 27E (171 mg, 0.407 mmol) in DMF (3 mL) was added TBS-Cl (307 mg, 2.034 mmol) and imidazole (138 mg, 2.034 mmol). The reaction was stirred at rt for 16 h, then quenched with H2O and extracted with EtOAc (2×). The solvent was removed and the residue was purified by flash column chromatography (0-60% EtOAc/hexanes) to give 27F (215 mg, 0.402 mmol, 99% yield). MS (ESI) m/z: 535.4 (M+H)+.

Provenance & Evidence