Potassium Acetate → HCID 131733877, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Acetate	HCID 517044	—
Reactant	Bis(neopentyl glycolato)diboron	HCID 2734316	—
Reactant	HCID 131733876	HCID 131733876	—
Catalyst	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Product	HCID 131733877	HCID 131733877	59.6%

Reaction Conditions

Temperature	85 °C

Reaction Steps

To a tube was added 28C (373 mg, 0.591 mmol), 5,5,5′,5′-tetramethyl-2,2′-bi(1,3,2-dioxaborinane) (160 mg, 0.709 mmol), potassium acetate (145 mg, 1.477 mmol), Pd(dppf)Cl2 (97 mg, 0.118 mmol) in DMSO (1.5 ml). The tube was filled with Ar, sealed and stirred at 85° C. for 2 h. The mixture was quenched with water, extracted with EtOAc (3×20 ml). The combined organic layer was filtered though silica gel and concentrated. The crude product was purified by flash chromatography to give 28D (210 mg, 0.352 mmol, 59.6% yield). MS (ESI) m/z: 597.3 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09174974B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-70e337889b644c62acda7feb7d039c31
Source note	uspto-grants-2015_11