HCID 123288403, compound → HCID 123854094, compound

Participants

Reaction Steps

To a degassed solution of 33B (573 mg, 1.131 mmol) in MeOH (10 mL), was added 10% Pd—C (50 mg, 0.047 mmol). The mixture was evacuated and flushed with H2 (3×), then was stirred under an atmosphere of H2 for 8 h. The mixture was filtered and concentrated to give 33C (382 mg, 1.115 mmol, 99% yield) as a pale brown oil. MS (ESI) m/z: 343.1 [M+1]+. 1H NMR (400 MHz, chloroform-d) δ ppm 6.40 (1H, d, J=1.8 Hz) 6.33 (1H, dd, J=12.5, 2.8 Hz) 4.20 (1H, sxt, J=5.7 Hz) 3.62-3.79 (4H, m) 3.53 (2H, br. s.) 2.40 (3H, s) 1.25 (3H, d, J=6.3 Hz) 0.89 (9H, s) 0.05 (6H, s).

Provenance & Evidence