Hydrochloric Acid → HCID 118092967, compound

Participants

Reaction Steps

36G (0.254 g, 0.633 mmol) was dissolved in EtOAc (3 mL) and dichloromethane (2 mL), then HCl (4M in dioxane) (2 mL, 8.00 mmol) was added. The reaction mixture was stirred for 4 h at rt. The solvent was removed under reduced pressure, and the residue was dried under high vacuum to give 36H (0.170 g, 0.620 mmol, 98% yield) as an off-white solid. MS (ESI) m/z: 202.2 [M+1]+. 1H NMR: (400 MHz, CD3OD) δ ppm 7.70 (1H, d, J=2.01 Hz), 7.67 (1H, d, J=8.28 Hz), 7.45 (1H, dd, J=8.28, 2.01 Hz), 4.61 (2H, s), 2.92 (3H, s), 1.82-1.88 (2H, m), 1.50-1.57 (2H, m).

Provenance & Evidence