Triphenylphosphine → HCID 118101202, compound

Participants

Role	Name	HCID	Charge
Reactant	Triphenylphosphine	HCID 11776	—
Reactant	(S)-(+)-3-Hydroxytetrahydrofuran	HCID 2733227	—
Reactant	Diisopropyl azodicarboxylate	HCID 5363146	—
Reactant	HCID 70292396	HCID 70292396	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 118101202	HCID 118101202	100.3%

Reaction Conditions

Temperature	0 °C

Reaction Steps

To a solution of 17D (566 mg, 1.885 mmol), (S)-tetrahydrofuran-3-ol (365 mg, 4.15 mmol) and PPh3 (1088 mg, 4.15 mmol) in THF (5 mL) was added DIAD (0.822 mL, 4.15 mmol) dropwise. The reaction was stirred at 0° C. for 0.5 h and then at rt for 16 h. The mixture was concentrated and purified by prep HPLC to give 38A (700 mg, 1.890 mmol, 100% yield). MS (ESI) m/z: 371.2 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09174974B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-c74caf380b6a4a19923ba403e282850a
Source note	uspto-grants-2015_11