Diisopropylethylamine → HCID 131733881, compound

Participants

Reaction Steps

To 38B (200 mg, 0.639 mmol) and DIEA (0.445 ml, 2.55 mmol) in DMF (10 mL), was added N-(benzyloxycarbonyloxy) succinimide (167 mg, 0.671 mmol). The mixture was stirred at rt for 1 h, then quenched with H2O. The mixture was extracted with EtOAc (3×) and the organic layer was washed with 1N HCl, sat. NaHCO3, brine, and dried over Na2SO4. The crude was purified by flash column chromatography (0-60% EtOAc/hexanes) to give 38C (182 mg, 0.486 mmol, 76% yield). MS (ESI) m/z: 375.3 (M+H)+.

Provenance & Evidence