Potassium Acetate → HCID 131733884, compound

Participants

Reaction Conditions

Reaction Steps

To a reaction tube was added 38D (258 mg, 0.410 mmol), 5,5,5′,5′-tetramethyl-2,2′-bi(1,3,2-dioxaborinane) (111 mg, 0.492 mmol), KOAc (101 mg, 1.025 mmol) and Pd(dppf)Cl2 (67.4 mg, 0.082 mmol) in DMSO (1.5 ml). The tube was filled with Ar, sealed and stirred at 85° C. for 2 h. The mixture was quenched with H2O, and extracted with EtOAc (3×). The combined organic layers was filtered though silica gel and concentrated. The residue was purified by prep HPLC to give 38E (171 mg, 0.288 mmol, 70.2% yield) as a tan solid. MS (ESI) m/z: 595.4 (M+H)+.

Provenance & Evidence