2,5-Dichloropyrimidine → HCID 57824529, compound

HRID 708970Notes

Reaction equation

HRID 708970 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5](Cl)=[CH:4][N:3]=1.[F:9][C:10]([F:22])([F:21])[O:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>[Pd]>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:15]2[CH:14]=[CH:13][C:12]([O:11][C:10]([F:9])([F:21])[F:22])=[CH:17][CH:16]=2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 27343864-(Trifluoromethoxy)phenylboronic acid

Product 1

HCID 57824529HCID 57824529, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The compound was prepared by palladium-catalyzed arylation of 2,5-dichloropyrimidine with 4-trifluoromethoxyphenyl boronic acid.

Sources & evidence

ORD record
ord-ade65a4a0b424d81ad99e93174ec7a2d
Source dataset
uspto-grants-2015_11
Patent number
US09179681B2

Reaction notes

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