反应详情

A flask containing a solution of 2,3-dimethoxy-5-[(E)-2-phenylethenyl]pyridine (Intermediate 5) (0.07 g, 0.29 mmol) in ethanol (10 ml) was evacuated and flushed with nitrogen. Palladium (10% on carbon) (0.03 g, 0.03 mmol) was added and the reaction vessel was evacuated and flushed with nitrogen before being filled with hydrogen gas from a balloon and stirred at room temperature for 45 minutes. The catalyst was removed by filtration through a pad of celite which was then washed with ethanol (20 ml). The combined organics were concentrated in vacuo to give 2,3-dimethoxy-5-(2-phenylethyl)pyridine as a colourless oil (70 mg, 99%).

1. customwas evacuated
2. customflushed with nitrogen
3. customthe reaction vessel was evacuated
4. customflushed with nitrogen
5. additionbefore being filled with hydrogen gas from a balloon
6. customThe catalyst was removed by filtration through a pad of celite which
7. washwas then washed with ethanol (20 ml)
8. concentrationThe combined organics were concentrated in vacuo