3-Chloro-5-fluorobenzyl Bromide → 5-[(3-Chloro-5-fluorobenzyl)sulfanyl]-2,3-dimethoxypyridine

HRID 709028Notes

Reaction equation

HRID 709028 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][S:6][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[C:10]([O:13][CH3:14])=[N:11][CH:12]=1.BrCC1C=C([F:28])C=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[C:18]([F:28])[CH:19]=1)[CH2:5][S:6][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[C:10]([O:13][CH3:14])=[N:11][CH:12]=1

Participants

3

Reactant 2

HCID 27348343-Chloro-5-fluorobenzyl BromideHCID 711858335-(3-Chlorobenzylthio)-2,3-dimethoxypyridine2×

Product 1

HCID 711862245-[(3-Chloro-5-fluorobenzyl)sulfanyl]-2,3-dimethoxypyridine

Procedure

Prepared as described for 5-(3-chlorobenzylthio)-2,3-dimethoxypyridine (Intermediate 8) but using 1-(bromomethyl)-3-chloro-5-fluorobenzene instead of 1-(bromomethyl)-3-chlorobenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-26524f4fbb604da6b9247a6fd1753a0a
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

Loading…