2-(Chloromethyl)-3-methylpyridine → 3-(Methoxymethoxy)-1-(methoxymethyl)-5-([(3-methylpyridin-2-yl)methyl]sulfanyl)pyridin-2(1H)-one

HRID 709034Notes

Reaction equation

HRID 709034 reaction equation
C(C1C=CC(C[S:8][C:9]2[CH:10]=[C:11]([O:19][CH2:20][O:21][CH3:22])[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=2)=CC=1)C.Cl[CH2:26][C:27]1[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=1>>[CH3:22][O:21][CH2:20][O:19][C:11]1[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=[C:9]([S:8][CH2:26][C:27]2[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 130586822-(Chloromethyl)-3-methylpyridineHCID 867315275-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one2×

Product 1

HCID 867315293-(Methoxymethoxy)-1-(methoxymethyl)-5-([(3-methylpyridin-2-yl)methyl]sulfanyl)pyridin-2(1H)-one

Procedure

Prepared as described for 5-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one (Intermediate 17) but using 2-(chloromethyl)-3-methylpyridine instead of 1-(chloromethyl)-4-ethylbenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-628c60e1a3c34792939273b1e5e89b39
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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