Sodium Hydroxide → HCID 178524642, compound

HRID 70905Notes

Reaction equation

HRID 70905 reaction equation
C[O:2][C:3]([C:5]1[O:9][N:8]=[C:7]([OH:10])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[OH:10][C:7]1[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[O:9][N:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178498603HCID 178498603, compound

Product 1

HCID 178524642HCID 178524642, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-hydroxy-isoxazole-5-carboxylic acid methyl ester (286 mg, 2.0 mmol) in methanol (7 mL) is added 1N NaOH (4.0 mL, 4.0 mmol) and the mixture is stirred at room temperature for 18 hrs. The solvent is removed under reduced pressure and 4.0 mL of 1N HCl is added to the residue. The resulting solution is lyophilized to give the product which is used as is in subsequent reactions.

Workup

  1. customThe solvent is removed under reduced pressure and 4.0 mL of 1N HCl
  2. additionis added to the residue
  3. customto give the product which

Sources & evidence

ORD record
ord-f08a7453e3c149a290cb9e0d6cf8cc6b
Source dataset
uspto-grants-2014_09
Patent number
US08822534B2

Reaction notes

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