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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 709050Generated: October 30, 2026

4-Iodotoluene → 3-Hydroxy-5-[2-(3-methylphenyl)ethyl]pyridin-2(1H)-one

https://huagongshe.com/reaction/709050

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-IodotolueneHCID 12207—
Reactant2,3-Dimethoxy-5-[(2-methylphenyl)ethynyl]pyridineHCID 71186209—
Product3-Hydroxy-5-[2-(3-methylphenyl)ethyl]pyridin-2(1H)-oneHCID 71186321—

Reaction Steps

Prepared as described for 2,3-dimethoxy-5-[(2-methylphenyl)ethynyl]pyridine (Intermediate 33) but using 1-iodo-4-methylbenzene instead of 1-iodo-2-methylbenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09180122B2
Source datasetuspto-grants-2015_11
ORD IDord-120f967d24d547f6888167a2b434ea44
Source noteuspto-grants-2015_11