2,3-Dimethoxy-5-[(3-methylbenzyl)sulfanyl]pyridine → 3-Hydroxy-5-[(3-methylbenzyl)sulfanyl]pyridin-2(1H)-one

HRID 709060Notes

Reaction equation

HRID 709060 reaction equation
C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.C[O:18][C:19]1[C:24]([O:25]C)=[CH:23][C:22]([S:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=2)=[CH:21][N:20]=1>>[OH:25][C:24]1[C:19](=[O:18])[NH:20][CH:21]=[C:22]([S:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=2)[CH:23]=1

Participants

3

Reactant 2

HCID 711857862,3-Dimethoxy-5-[(3-methylbenzyl)sulfanyl]pyridine2×HCID 71187166HCID 71187166, compound

Product 1

HCID 711859493-Hydroxy-5-[(3-methylbenzyl)sulfanyl]pyridin-2(1H)-one

Procedure

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 1) from 2,3-dimethoxy-5-[(3-methylbenzyl)sulfanyl]pyridine (Intermediate 4).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8308cecb603f45939e2559b7ea0ae8ce
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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