5-[(2-Chlorobenzyl)sulfanyl]-2,3-dimethoxypyridine → 5-[(2-Chlorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

HRID 709062Notes

Reaction equation

HRID 709062 reaction equation
C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.[Cl:17][C:18]1[CH:35]=[CH:34][CH:33]=[CH:32][C:19]=1[CH2:20][S:21][C:22]1[CH:23]=[C:24]([O:30]C)[C:25]([O:28]C)=[N:26][CH:27]=1>>[Cl:17][C:18]1[CH:35]=[CH:34][CH:33]=[CH:32][C:19]=1[CH2:20][S:21][C:22]1[CH:23]=[C:24]([OH:30])[C:25](=[O:28])[NH:26][CH:27]=1

Participants

3

Reactant 2

HCID 711863175-[(2-Chlorobenzyl)sulfanyl]-2,3-dimethoxypyridine2×HCID 71187166HCID 71187166, compound

Product 1

HCID 711859775-[(2-Chlorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

Procedure

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 1) from 5-[(2-chlorobenzyl)sulfanyl]-2,3-dimethoxypyridine (Intermediate 10).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-56963d8dfd87422980dc4b8cd9820521
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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