2,3-Dimethoxy-5-{[3-(trifluoromethyl)benzyl]sulfanyl}pyridine → 3-Hydroxy-5-{[3-(trifluoromethyl)benzyl]sulfanyl}pyridin-2(1H)-one

HRID 709063Notes

Reaction equation

HRID 709063 reaction equation
C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.C[O:18][C:19]1[C:24]([O:25]C)=[CH:23][C:22]([S:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)=[CH:21][N:20]=1>>[OH:25][C:24]1[C:19](=[O:18])[NH:20][CH:21]=[C:22]([S:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:37])([F:36])[F:38])[CH:30]=2)[CH:23]=1

Participants

3

Reactant 2

HCID 711864592,3-Dimethoxy-5-{[3-(trifluoromethyl)benzyl]sulfanyl}pyridine2×HCID 71187166HCID 71187166, compound

Product 1

HCID 711873103-Hydroxy-5-{[3-(trifluoromethyl)benzyl]sulfanyl}pyridin-2(1H)-one

Procedure

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 1) from 2,3-dimethoxy-5-{[3-(trifluoromethyl)benzyl]sulfanyl}pyridine (Intermediate 11).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-335e9a3a11934dff9bce55758cc28e04
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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