2,3-Dimethoxy-5-[(2-methylbenzyl)sulfanyl]pyridine → 3-Hydroxy-5-[(2-methylbenzyl)sulfanyl]pyridin-2(1H)-one

HRID 709064Notes

Reaction equation

HRID 709064 reaction equation
C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.C[O:18][C:19]1[C:24]([O:25]C)=[CH:23][C:22]([S:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[CH3:35])=[CH:21][N:20]=1>>[OH:25][C:24]1[C:19](=[O:18])[NH:20][CH:21]=[C:22]([S:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[CH3:35])[CH:23]=1

Participants

3

Reactant 2

HCID 711864382,3-Dimethoxy-5-[(2-methylbenzyl)sulfanyl]pyridine2×HCID 71187166HCID 71187166, compound

Product 1

HCID 711871903-Hydroxy-5-[(2-methylbenzyl)sulfanyl]pyridin-2(1H)-one

Procedure

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 1) from 2,3-dimethoxy-5-[(2-methylbenzyl)sulfanyl]pyridine (Intermediate 12).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b21af6a848714a88a004e912bdc7fd52
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

Loading…