5-(4-Fluorobenzylthio)-2,3-dimethoxypyridine → 5-[(4-Fluorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

HRID 709066Notes

Reaction equation

HRID 709066 reaction equation
C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.[F:17][C:18]1[CH:35]=[CH:34][C:21]([CH2:22][S:23][C:24]2[CH:25]=[C:26]([O:32]C)[C:27]([O:30]C)=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:35]=[CH:34][C:21]([CH2:22][S:23][C:24]2[CH:25]=[C:26]([OH:32])[C:27](=[O:30])[NH:28][CH:29]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 711864345-(4-Fluorobenzylthio)-2,3-dimethoxypyridine2×HCID 71187166HCID 71187166, compound

Product 1

HCID 711872155-[(4-Fluorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

Procedure

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 1) from 5-(4-fluorobenzylthio)-2,3-dimethoxypyridine (Intermediate 14).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8af1eda3feaa4490b8d25c28e66356ce
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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