Hydrochloric Acid → HCID 71186095, compound

Participants

Reaction Steps

A solution of 5-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)-pyridin-2(1H)-one (253 mg, 0.724 mmol) (Intermediate 17) in hydrogen chloride solution (4 M in dioxane; 2.10 ml, 8.50 mmol) and dioxane (2 ml) was heated under reflux overnight. The reaction mixture was concentrated in vacuo and the resulting solid was recrystallised in boiling ethanol/water. The resulting recrystallised solid was filtered and dried to yield 5-[(4-ethylbenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one (45 mg, 0.17 mmol, 20% yield).

Provenance & Evidence