HCID 71187166, compound → 5-{[(5-Chloropyridin-2-yl)methyl]sulfanyl}-3-hydroxypyridin-2(1H)-one

HRID 709073Notes

Reaction equation

HRID 709073 reaction equation
C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:24][S:25][C:26]2[CH:27]=[C:28]([O:36]COC)[C:29](=[O:35])[N:30](COC)[CH:31]=2)=[N:22][CH:23]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:24][S:25][C:26]2[CH:27]=[C:28]([OH:36])[C:29](=[O:35])[NH:30][CH:31]=2)=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 71187166HCID 71187166, compoundHCID 867315345-{[(5-Chloropyridin-2-yl)methyl]sulfanyl}-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one2×

Product 1

HCID 711858625-{[(5-Chloropyridin-2-yl)methyl]sulfanyl}-3-hydroxypyridin-2(1H)-one

Procedure

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 12) from 5-{[(5-chloropyridin-2-yl)methyl]sulfanyl}-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one (Intermediate 24).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a7fc933bbc244b9d828adfa15faafcaf
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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