HCID 71187166, compound → 5-[(3,4-Difluorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

HRID 709074Notes

Reaction equation

HRID 709074 reaction equation
C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.[F:17][C:18]1[CH:19]=[C:20]([CH:37]=[CH:38][C:39]=1[F:40])[CH2:21][S:22][C:23]1[CH:24]=[C:25]([O:33]COC)[C:26](=[O:32])[N:27](COC)[CH:28]=1>>[F:17][C:18]1[CH:19]=[C:20]([CH:37]=[CH:38][C:39]=1[F:40])[CH2:21][S:22][C:23]1[CH:24]=[C:25]([OH:33])[C:26](=[O:32])[NH:27][CH:28]=1

Participants

3

Reactant 2

HCID 71187166HCID 71187166, compoundHCID 867315355-[(3,4-Difluorobenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one2×

Product 1

HCID 711872035-[(3,4-Difluorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

Procedure

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 12) from 5-[(3,4-difluorobenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one (Intermediate 25).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f3041de81cc141e785081c0df80ffded
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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