HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dimethoxy-5-(2-phenylethyl)pyridine → 3-Hydroxy-5-(2-Phenylethyl)pyridin-2(1h)-One
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dimethoxy-5-(2-phenylethyl)pyridine | HCID 71185819 | — |
| Reactant | 3-hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-one | HCID 71187170 | — |
| Product | 3-Hydroxy-5-(2-Phenylethyl)pyridin-2(1h)-One | HCID 71187181 | 16% |
Reaction Steps
Prepared as described for 3-Hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-one (Example 26) from 2,3-dimethoxy-5-(2-phenylethyl)pyridine (Intermediate 6). Purification by column chromatography (C18-SiO2; 5-95% methanol in water with 0.01% formic acid) gave 3-hydroxy-5-(2-phenylethyl)pyridin-2(1H)-one as a purple solid (10 mg, 16%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09180122B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-f92198b9374144de9729ee9ad869d055 |
| Source note | uspto-grants-2015_11 |