Hydrochloric Acid → HCID 71187214, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(benzylsulfonyl)-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one (Intermediate 40; 75 mg, 0.212 mmol) in dioxane (0.7 ml) and methanol (0.8 ml) was added hydrogen chloride (4.0 M in dioxane, 1.597 ml, 6.39 mmol) and the reaction irradiated in the microwave with heating to 120° C. for 10 minutes. The resulting white precipitate that had formed was filtered and washed with ethanol to yield 5-(benzylsulfonyl)-3-hydroxypyridin-2(1H)-one (25 mg, 44%).

Provenance & Evidence