HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 90054447, compound → (R)-methyl 4-(2-(3,3-difluoro-5-formyl-2-oxopyrrolidin-1-yl)ethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 90054447 | HCID 90054447 | — |
| Reactant | (R)-methyl 7-(3,3-difluoro-5-(hydroxymethyl)-2-oxopyrrolidin-1-yl)heptanoate | HCID 90054523 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | (R)-methyl 4-(2-(3,3-difluoro-5-formyl-2-oxopyrrolidin-1-yl)ethyl)benzoate | HCID 90054501 | — |
Reaction Steps
(R)-methyl 4-(2-(3,3-difluoro-5-formyl-2-oxopyrrolidin-1-yl)ethyl)benzoate was prepared from 12b using the oxidation procedure (Step K) described for the preparation of intermediate 13a from intermediate 12a; TLC Rf 0.4 (solvent system: 95:5 v/v dichloromethane-methanol); 1H-NMR (CDCl3) δ 9.2 (s, 1H), 7.9 (dd, 2H), 7.24 (dd, 2H), 3.98-3.91 (m, 1H), 3.87 (s, 3H), 3.74-3.48 (m, 2H), 3.51-3.46 (m, 2H), 3.1-2.8 (m, 2H), 2.48-2.22 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09180116B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-8c4180296f1c47ce899ff31c616967c8 |
| Source note | uspto-grants-2015_11 |