HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-3-amino-4-(3'-chloro-biphenyl-4-yl)-2-hydroxy-butyric acid methyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-3-tert-butoxycarbonylamino-4-(3'-chloro-biphenyl-4-yl)-2-hydroxy-butyric acid methyl ester | HCID 67208772 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-3-amino-4-(3'-chloro-biphenyl-4-yl)-2-hydroxy-butyric acid methyl ester hydrochloride | HCID 68423710 | — |
Reaction Steps
(R)-3-tert-butoxycarbonylamino-4-(3′-chloro-biphenyl-4-yl)-2-hydroxy-butyric acid methyl ester (113 mg, 0.269 mmol) is treated with 4M HCl in dioxane (2 mL). After being stirred at room temperature for 1 h, the reaction mixture is concentrated. The residue is used for a next step without further purification. HPLC retention time=1.22, 1.29 minutes (condition A): MS (m+1)=320.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822534B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-118f630230b34c4089ec34232ea4e540 |
| Source note | uspto-grants-2014_09 |