Hydrochloric Acid → HCID 58460122, compound

Participants

Reaction Steps

91 ml of a 3N aqueous sodium hydroxide solution were added to 21.43 g (67.9 mmol) of the compound of Example 1A, and the mixture was heated at reflux overnight. After cooling to RT, the mixture was adjusted to pH 1 by slow addition of about 20% strength hydrochloric acid. The precipitated solid was isolated by filtration, washed with water and dried under reduced pressure at 60° C. This gave 17.55 g of the title compound in a purity of about 88% (90% of theory).

Provenance & Evidence