Lithium Hydroxide → HCID 59536933, compound

Participants

Reaction Steps

The enantiomerically pure compound of Example 6A (1.6 g, 4.21 mmol) was dissolved in 77 ml of methanol, and 17 ml of a 1M solution of lithium hydroxide in water were added. The mixture was stirred at RT for 1 h and then concentrated on a rotary evaporator. The residue was diluted with 100 ml of water and acidified to pH 1-2 with 1 N hydrochloric acid. The precipitated product was filtered off, washed successively with water and cyclohexane and sucked dry. Further drying under high vacuum gave 1.1 g (71% of theory) of the title compound.

Provenance & Evidence