N-[1-(2-Chlorophenyl)-2-nitroethyl]methanesulphonamide → N-[2-Amino-1-(2-chlorophenyl)ethyl]methanesulphonamide

Participants

Reaction Steps

A solution of 221 mg (0.79 mmol) of the compound of Example 26A in 45 ml of methanol was hydrogenated in a continuous-flow hydrogenation apparatus fitted with a Raney-nickel cartridge (H-Cube from Thales Nano, Budapest, Model HC-2-SS) at a flow rate of 1 ml/min, a temperature of 45° C. and at standard pressure. After the reaction had ended, the solution was freed from the methanol on a rotary evaporator and the residue was dried briefly under high vacuum. This gave 186 mg (94% of theory) of the title compound.

Provenance & Evidence