Potassium cyanate → 1-[1-(2-Chlorophenyl)-2-nitroethyl]urea

Participants

Reaction Conditions

Reaction Steps

At RT, 300 mg (about 93% pure, 1.18 mmol) of the compound of Example 25A were initially charged in 12 ml of water/methanol (1:1 v/v), and 287 mg (3.53 mmol) of potassium cyanate were added. The reaction mixture was warmed to 40° C. for 1 h. After cooling to RT, the mixture was directly separated into its components by preparative HPLC [Method 8]. This gave 120 mg (41% of theory) of the title compound.

Provenance & Evidence