Methanesulfonyl chloride → HCID 87085233, compound

Participants

Reaction Steps

At RT, 13 μl of methanesulphonyl chloride were added to a solution of 90 mg (0.15 mmol) of the compound of Example 56A in 1.5 ml of pyridine. The mixture was stirred at RT for 1 h, and another 12 ml of methanesulphonyl chloride were added (0.32 mmol, 2.1 eq. in total). After 1 h, the volatile components were removed on a rotary evaporator. The residue was dissolved in a little DMSO and purified by preparative HPLC [Method 8]. This gave 59 mg (61% of theory) of the title compound.

Provenance & Evidence