Methanesulfonyl chloride → HCID 87085233, compound

HRID 709151Notes

Reaction equation

Cl.[NH2:2][CH:3]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]([F:38])([F:37])[F:36])[CH2:4][NH:5][C:6](=[O:28])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)=[N:9]1.[CH3:39][S:40](Cl)(=[O:42])=[O:41]>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([C:10]2[N:11]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:12](=[O:13])[N:8]([CH2:7][C:6]([NH:5][CH2:4][CH:3]([NH:2][S:40]([CH3:39])(=[O:42])=[O:41])[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]([F:38])([F:37])[F:36])=[O:28])[N:9]=2)=[CH:22][CH:23]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 89764326HCID 89764326, compound

Product 1

HCID 87085233HCID 87085233, compound

Procedure

Analogously to Example 16, treatment of 67 mg (0.114 mmol) of the compound of Example 57A with methanesulphonyl chloride gave 40 mg (56% of theory) of the title compound.

Sources & evidence

ORD record: ord-cdcda934b0e04d90a5c2ce366e86ee08
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09180120B2

Reaction notes

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