Methanesulfonyl chloride → HCID 56848688, compound

HRID 709152Notes

Reaction equation

HRID 709152 reaction equation
Cl.[NH2:2][CH:3]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[C:30]=1[Cl:36])[CH2:4][NH:5][C:6](=[O:28])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)=[N:9]1.[CH3:37][S:38](Cl)(=[O:40])=[O:39]>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([C:10]2[N:11]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:17])[F:19])[C:12](=[O:13])[N:8]([CH2:7][C:6]([NH:5][CH2:4][CH:3]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[C:30]=3[Cl:36])[NH:2][S:38]([CH3:37])(=[O:40])=[O:39])=[O:28])[N:9]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 89764468HCID 89764468, compound

Product 1

HCID 56848688HCID 56848688, compound

Procedure

Analogously to Example 16, treatment of 77 mg (0.131 mmol) of the compound of Example 54A with methanesulphonyl chloride gave 55 mg (67% of theory) of the title compound.

Sources & evidence

ORD record
ord-d7ba8f348dd44b00b9f4a62a4fcc7978
Source dataset
uspto-grants-2015_11
Patent number
US09180120B2

Reaction notes

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