Methanol → HCID 87099630, compound

Participants

Reaction Conditions

Reaction Steps

12 mg of potassium cyanate (153 μmol) were added to a mixture of 30 mg (51 μmol) of the compound of Example 54A, 1 ml of water and 1 ml of methanol, and the mixture was stirred at 40° C. for 1.5 h. An additional 6 mg (75 μmol) of potassium cyanate were added, and stirring of the reaction mixture was continued at RT overnight. A few ml of DMSO were added, and the entire solution was separated by preparative HPLC [Method 8]. The product fraction was freed from the solvent on a rotary evaporator and the residue was dried under high vacuum. This gave 17 mg (56% of theory) of the title compound.

Provenance & Evidence